The persistent inflammatory state is common in diabetes and chronic kidney disease (CKD). These patients present exercise\r\nintolerance and increased arterial stiffness. Long-term aerobic exercise has been associated with better arterial compliance,\r\nantidiabetic and antiinflammatory benefits. We assessed the hypothesis that in patients with diabetes and CKD, better aerobic\r\ncapacity is associated with less inflammatory state and arterial stiffness. Thirty-nine CKD patients (17 in hemodialysis) were\r\nevaluated. According to CKD etiology two patient groups were obtained: group of diabetics (GD) was formed by 11 patients and\r\nnondiabetics (GND) formed by 28 patients. Central blood pressure and arterial stiffness were evaluated by Sphygmocor device.\r\nCarotida intima-media thickness (CA-IMT) was evaluated by ultrasonography. Aerobic capacity was measured by estimated\r\nVO2max according to treadmill test by Bruce protocol. The GD showed a higher frequency of C-reactive protein above laboratory\r\ncutoff (P = 0.044), higher frequency of male gender, and a non significant higher value of VO2max (P = 0.099). The CA-IMT was\r\nsimilar. Only better aerobic capacity was associated with lower frequency of high C-reactive protein when adjusted to diabetes and\r\ngender in a logistic regression model. In conclusion, aerobic capacity was associated with inflammatory state, in CKD patients,\r\nindependently of diabetes presence.
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